Ischemic stroke is associated with the ABO locus: The EuroCLOT study
Identifieur interne : 004A31 ( Main/Exploration ); précédent : 004A30; suivant : 004A32Ischemic stroke is associated with the ABO locus: The EuroCLOT study
Auteurs : Frances M. K. Williams [Royaume-Uni] ; Angela M. Carter [Royaume-Uni] ; Pirro G. Hysi [Royaume-Uni] ; Gabriela Surdulescu [Royaume-Uni] ; Dylan Hodgkiss [Royaume-Uni] ; Nicole Soranzo [Royaume-Uni, États-Unis, Finlande] ; Matthew Traylor [Royaume-Uni] ; Steve Bevan [Royaume-Uni] ; Martin Dichgans [Allemagne] ; Peter M. W. Rothwell [Royaume-Uni] ; Cathie Sudlow [Royaume-Uni] ; Martin Farrall [Royaume-Uni] ; Kaisa Silander [Finlande] ; Mari Kaunisto [Finlande] ; Peter Wagner [Finlande] ; Olli Saarela [Finlande] ; Kari Kuulasmaa [Finlande] ; Jarmo Virtamo [Finlande] ; Veikko Salomaa [Finlande] ; Philippe Amouyel [France] ; Dominique Arveiler [France] ; Jean Ferrieres [France] ; Per-Gunnar Wiklund [Suède] ; M. Arfan Ikram [Pays-Bas] ; Albert Hofman [Pays-Bas] ; Giorgio B. Boncoraglio [Italie] ; Eugenio A. Parati [Italie] ; Anna Helgadottir [Royaume-Uni, Islande] ; Solveig Gretarsdottir [Islande] ; Unnur Thorsteinsdottir [Islande] ; Gudmar Thorleifsson [Islande] ; Kari Stefansson [Islande] ; Sudha Seshadri [États-Unis] ; Anita Destefano [États-Unis] ; Andreas Gschwendtner [Allemagne] ; Bruce Psaty [États-Unis] ; Will Longstreth [États-Unis] ; Braxton D. Mitchell [Royaume-Uni] ; Yu-Ching Cheng [Royaume-Uni] ; Robert Clarke [Italie] ; Marco Ferrario [États-Unis] ; Joshua C. Bis [Australie] ; Christopher Levi [Australie, États-Unis] ; John Attia [Australie, États-Unis] ; Elizabeth G. Holliday [Australie, États-Unis] ; Rodney J. Scott [Australie, États-Unis] ; Myriam Fornage [Royaume-Uni] ; Pankaj Sharma [États-Unis] ; Karen L. Furie [États-Unis] ; Jonathan Rosand [États-Unis] ; Mike Nalls [États-Unis] ; James Meschia [États-Unis] ; Thomas H. Mosely [Royaume-Uni] ; Alun Evans ; Aarno Palotie [Royaume-Uni, États-Unis, Finlande] ; Hugh S. Markus [Royaume-Uni] ; Peter J. Grant [Royaume-Uni] ; Tim D. Spector [Royaume-Uni]Source :
- Annals of Neurology [ 0364-5134 ] ; 2013-01.
Descripteurs français
- Wicri :
- geographic : Finlande.
- topic : Maladie cardio-vasculaire, Consortium, épidémiologie, Génétique, Recherche médicale, Neurologie, Santé publique, Recherche scientifique.
English descriptors
- KwdEn :
- Acute ischemic stroke, Additional support, Aiden corvin, Allele, Aric, Arterioscler thromb vasc biol, Asgc, Assay, Association studies, Association study, Atherosclerosis, Atherosclerosis risk, Atrial fibrillation, Australian stroke genetics, Beta, Blood group, Blood groups, Board membership, Body mass index, Boehringer ingelheim, Brain imaging, Cambridge institute, Cambridge school, Candidate genes, Cardioembolic, Cardioembolic stroke, Cardiovascular, Cardiovascular disease, Cardiovascular health study, Cedir, Centre, Cerebral circulation, Child health research, Clinical collections, Clinical medicine, Clinical neurosciences, Coagulation, Coagulation factors, Cohort, College london, Communities study, Complex disease genetics, Confidence interval, Consortium, Coronary artery disease, Coronary atherosclerosis, Dementia research centre, Diabetes research, Early onset stroke study, Edinburgh, Effect size, Effects model, Epidemiology, Euroclot, Euroclot study, Extensive phenotyping, Factor viii, Fibrin, Fibrin clot phenotypes, Finland, Forest plot, Foundation trust, Framingham, Framingham heart study, Funding, Fviii, Fviii levels, Fxiii, Fxiii activity, Fxiiia, Gasros, Genet, Genetic, Genetic epidemiology, Genetic variants, Genetics, Genome, Genotype, Genotyping, Grant number, Grant numbers, Health partners, Health research, Health services, Healthy families, Healthy volunteers, Heart protection study, Hemostatic factors, Historical reasons, Hospital genes, Human genetics, Important contributions, Independent snps, Ines barroso, Intramural research program, Ischemic, Ischemic stroke, Ischemic stroke cases, Ischemic stroke genetics study, Ischemic stroke study, Isgs, January, Locus, Locus table, Medical research, Metastroke, Metastroke consortium, Molecular genetics, Molecular medicine, Monica risk, Morgam, Morgam cohorts, Morgam project, Myocardial infarction, National institute, Neurology, Neurology table, Neuropsychiatric genetics research group, Nhlbi contracts, Odds ratio, Outcome study, Pankaj sharma, Panos deloukas, Phenotype, Polymorphism, Positive results, Project grant, Public health, Quality control, Queensland diamantina institute, Regression analysis, Research centre, Research excellence, Research facility, Risk factors, Rotterdam, Rotterdam study, Same region, Sample size, Scientific research, Significant association, Significant associations, Single nucleotide polymorphism, Single nucleotide polymorphisms, Small effect, Snp, Standard deviation, Standard error, Stroke, Stroke association, Stroke cases, Stroke risk, Stroke subtype, Stroke subtypes, Stroke subtyping, Study design, Study group, Study groups, Subgroup analysis, Subtypes, Subunit, Supplementary table, Systematic review, Telethon institute, Thromb, Thromb haemost, Trinity college dublin, Turbidimetric assay, Twin research, Twinsuk, Variant, Vascular health, Veterans affairs, Wellcome, Wellcome trust, Wellcome trust case control consortium, Wellcome trust centre, Wellcome trust genome campus, Wellcome trust sanger centre, Western australia, Willebrand factor, Wtccc2, Wtccc2 controls.
- Teeft :
- Acute ischemic stroke, Additional support, Aiden corvin, Allele, Aric, Arterioscler thromb vasc biol, Asgc, Assay, Association studies, Association study, Atherosclerosis, Atherosclerosis risk, Atrial fibrillation, Australian stroke genetics, Beta, Blood group, Blood groups, Board membership, Body mass index, Boehringer ingelheim, Brain imaging, Cambridge institute, Cambridge school, Candidate genes, Cardioembolic, Cardioembolic stroke, Cardiovascular, Cardiovascular disease, Cardiovascular health study, Cedir, Centre, Cerebral circulation, Child health research, Clinical collections, Clinical medicine, Clinical neurosciences, Coagulation, Coagulation factors, Cohort, College london, Communities study, Complex disease genetics, Confidence interval, Consortium, Coronary artery disease, Coronary atherosclerosis, Dementia research centre, Diabetes research, Early onset stroke study, Edinburgh, Effect size, Effects model, Epidemiology, Euroclot, Euroclot study, Extensive phenotyping, Factor viii, Fibrin, Fibrin clot phenotypes, Finland, Forest plot, Foundation trust, Framingham, Framingham heart study, Funding, Fviii, Fviii levels, Fxiii, Fxiii activity, Fxiiia, Gasros, Genet, Genetic, Genetic epidemiology, Genetic variants, Genetics, Genome, Genotype, Genotyping, Grant number, Grant numbers, Health partners, Health research, Health services, Healthy families, Healthy volunteers, Heart protection study, Hemostatic factors, Historical reasons, Hospital genes, Human genetics, Important contributions, Independent snps, Ines barroso, Intramural research program, Ischemic, Ischemic stroke, Ischemic stroke cases, Ischemic stroke genetics study, Ischemic stroke study, Isgs, January, Locus, Locus table, Medical research, Metastroke, Metastroke consortium, Molecular genetics, Molecular medicine, Monica risk, Morgam, Morgam cohorts, Morgam project, Myocardial infarction, National institute, Neurology, Neurology table, Neuropsychiatric genetics research group, Nhlbi contracts, Odds ratio, Outcome study, Pankaj sharma, Panos deloukas, Phenotype, Polymorphism, Positive results, Project grant, Public health, Quality control, Queensland diamantina institute, Regression analysis, Research centre, Research excellence, Research facility, Risk factors, Rotterdam, Rotterdam study, Same region, Sample size, Scientific research, Significant association, Significant associations, Single nucleotide polymorphism, Single nucleotide polymorphisms, Small effect, Snp, Standard deviation, Standard error, Stroke, Stroke association, Stroke cases, Stroke risk, Stroke subtype, Stroke subtypes, Stroke subtyping, Study design, Study group, Study groups, Subgroup analysis, Subtypes, Subunit, Supplementary table, Systematic review, Telethon institute, Thromb, Thromb haemost, Trinity college dublin, Turbidimetric assay, Twin research, Twinsuk, Variant, Vascular health, Veterans affairs, Wellcome, Wellcome trust, Wellcome trust case control consortium, Wellcome trust centre, Wellcome trust genome campus, Wellcome trust sanger centre, Western australia, Willebrand factor, Wtccc2, Wtccc2 controls.
Abstract
Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.
Url:
- https://api.istex.fr/document/D0F2D2BA276B4E6F0AD59BAEEE8BC10933482839/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582024
DOI: 10.1002/ana.23838
Affiliations:
- Allemagne, Australie, Finlande, France, Islande, Italie, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Alsace (région administrative), Angleterre, Bavière, District de Haute-Bavière, Floride, Grand Est, Grand Londres, Hauts-de-France, Hollande-Méridionale, Maryland, Massachusetts, Midi-Pyrénées, Nord-Pas-de-Calais, Occitanie (région administrative), Oxfordshire, Texas, Uusimaa, Washington (État), Yorkshire-et-Humber, Écosse, État du Mississippi
- Helsinki, Leeds, Lille, Londres, Munich, Oxford, Rotterdam, Strasbourg, Toulouse, Édimbourg
- Université d'Helsinki, Université d'Oxford, Université d'Édimbourg, Université de Leeds, Université de Londres
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Le document en format XML
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K." last="Williams">Frances M. K. Williams</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country></affiliation><affiliation></affiliation></author><author><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M. W." last="Rothwell">Peter M. W. Rothwell</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke Prevention Research Unit, University Department of Clinical Neurology, Oxford University, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Clinical Neurosciences, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Chronic Disease Epidemiology and Prevention Unit, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology, Faculty of Medicine, Toulouse‐Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Wiklund, Per Unnar" sort="Wiklund, Per Unnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Internal Medicine, University of Umeo̊, Umeo̊</wicri:regionArea><wicri:noRegion>Umeo̊</wicri:noRegion></affiliation></author><author><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea><wicri:noRegion>”Milan</wicri:noRegion></affiliation></author><author><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurology, Research Hospital of the Neurological Institute “Carlo Besta,”Milan</wicri:regionArea><wicri:noRegion>”Milan</wicri:noRegion></affiliation></author><author><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Centre for Human Genetics and Department of Cardiovascular Medicine, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><country xml:lang="fr">Islande</country><wicri:regionArea>DeCODE Genetics, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University Schools of Medicine and Public Health, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Health Services, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität Munich, Ludwig‐Maximilians‐University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Psaty, Bruce" sort="Psaty, Bruce" uniqKey="Psaty B" first="Bruce" last="Psaty">Bruce Psaty</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Group Health Research Institute, Group Health, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Neurology, University of Washington</wicri:cityArea></affiliation></author><author><name sortKey="Longstreth, Will" sort="Longstreth, Will" uniqKey="Longstreth W" first="Will" last="Longstreth">Will Longstreth</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Epidemiology, Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Medicine, and Health Services, University of Washington, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Medicine, University of Maryland, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Cheng, Yu Hing" sort="Cheng, Yu Hing" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Clinical Trial Service Unit, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>University of Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>University of Newcastle, Callaghan</wicri:regionArea><wicri:noRegion>Callaghan</wicri:noRegion></affiliation></author><author><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, New Lambton Heights</wicri:regionArea><wicri:noRegion>New Lambton Heights</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Hunter Medical Research Institute, New Lambton</wicri:regionArea><wicri:noRegion>New Lambton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial College Cerebrovascular Research Unit, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Jacksonville, FL</wicri:regionArea><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Nalls, Mike" sort="Nalls, Mike" uniqKey="Nalls M" first="Mike" last="Nalls">Mike Nalls</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Meschia, James" sort="Meschia, James" uniqKey="Meschia J" first="James" last="Meschia">James Meschia</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État du Mississippi</region></placeName><wicri:cityArea>University of Mississippi Medical Center, Jackson</wicri:cityArea></affiliation></author><author><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H." last="Mosely">Thomas H. Mosely</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Queen's University of Belfast, Belfast</wicri:regionArea><wicri:noRegion>Belfast</wicri:noRegion></affiliation></author><author><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton</wicri:regionArea><wicri:noRegion>Hinxton</wicri:noRegion></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Program in Medical and Population Genetics and Genetic Analysis Platform, Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Finlande</country><wicri:regionArea>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute for Molecular Medicine Finland, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke and Dementia Research Centre, St George's University of London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region><settlement type="city">Londres</settlement></placeName><orgName type="university">Université de Londres</orgName></affiliation></author><author><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Cardiovascular and Diabetes Research, University of Leeds, Leeds</wicri:regionArea><orgName type="university">Université de Leeds</orgName><placeName><settlement type="city">Leeds</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Yorkshire-et-Humber</region></placeName></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of Neurology</title><title level="j" type="alt">ANNALS OF NEUROLOGY</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><biblScope unit="vol">73</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="16">16</biblScope><biblScope unit="page" to="31">31</biblScope><biblScope unit="page-count">16</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2013-01">2013-01</date></imprint><idno type="ISSN">0364-5134</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acute ischemic stroke</term><term>Additional support</term><term>Aiden corvin</term><term>Allele</term><term>Aric</term><term>Arterioscler thromb vasc biol</term><term>Asgc</term><term>Assay</term><term>Association studies</term><term>Association study</term><term>Atherosclerosis</term><term>Atherosclerosis risk</term><term>Atrial fibrillation</term><term>Australian stroke genetics</term><term>Beta</term><term>Blood group</term><term>Blood groups</term><term>Board membership</term><term>Body mass index</term><term>Boehringer ingelheim</term><term>Brain imaging</term><term>Cambridge institute</term><term>Cambridge school</term><term>Candidate genes</term><term>Cardioembolic</term><term>Cardioembolic stroke</term><term>Cardiovascular</term><term>Cardiovascular disease</term><term>Cardiovascular health study</term><term>Cedir</term><term>Centre</term><term>Cerebral circulation</term><term>Child health research</term><term>Clinical collections</term><term>Clinical medicine</term><term>Clinical neurosciences</term><term>Coagulation</term><term>Coagulation factors</term><term>Cohort</term><term>College london</term><term>Communities study</term><term>Complex disease genetics</term><term>Confidence interval</term><term>Consortium</term><term>Coronary artery disease</term><term>Coronary atherosclerosis</term><term>Dementia research centre</term><term>Diabetes research</term><term>Early onset stroke study</term><term>Edinburgh</term><term>Effect size</term><term>Effects model</term><term>Epidemiology</term><term>Euroclot</term><term>Euroclot study</term><term>Extensive phenotyping</term><term>Factor viii</term><term>Fibrin</term><term>Fibrin clot phenotypes</term><term>Finland</term><term>Forest plot</term><term>Foundation trust</term><term>Framingham</term><term>Framingham heart study</term><term>Funding</term><term>Fviii</term><term>Fviii levels</term><term>Fxiii</term><term>Fxiii activity</term><term>Fxiiia</term><term>Gasros</term><term>Genet</term><term>Genetic</term><term>Genetic epidemiology</term><term>Genetic variants</term><term>Genetics</term><term>Genome</term><term>Genotype</term><term>Genotyping</term><term>Grant number</term><term>Grant numbers</term><term>Health partners</term><term>Health research</term><term>Health services</term><term>Healthy families</term><term>Healthy volunteers</term><term>Heart protection study</term><term>Hemostatic factors</term><term>Historical reasons</term><term>Hospital genes</term><term>Human genetics</term><term>Important contributions</term><term>Independent snps</term><term>Ines barroso</term><term>Intramural research program</term><term>Ischemic</term><term>Ischemic stroke</term><term>Ischemic stroke cases</term><term>Ischemic stroke genetics study</term><term>Ischemic stroke study</term><term>Isgs</term><term>January</term><term>Locus</term><term>Locus table</term><term>Medical research</term><term>Metastroke</term><term>Metastroke consortium</term><term>Molecular genetics</term><term>Molecular medicine</term><term>Monica risk</term><term>Morgam</term><term>Morgam cohorts</term><term>Morgam project</term><term>Myocardial infarction</term><term>National institute</term><term>Neurology</term><term>Neurology table</term><term>Neuropsychiatric genetics research group</term><term>Nhlbi contracts</term><term>Odds ratio</term><term>Outcome study</term><term>Pankaj sharma</term><term>Panos deloukas</term><term>Phenotype</term><term>Polymorphism</term><term>Positive results</term><term>Project grant</term><term>Public health</term><term>Quality control</term><term>Queensland diamantina institute</term><term>Regression analysis</term><term>Research centre</term><term>Research excellence</term><term>Research facility</term><term>Risk factors</term><term>Rotterdam</term><term>Rotterdam study</term><term>Same region</term><term>Sample size</term><term>Scientific research</term><term>Significant association</term><term>Significant associations</term><term>Single nucleotide polymorphism</term><term>Single nucleotide polymorphisms</term><term>Small effect</term><term>Snp</term><term>Standard deviation</term><term>Standard error</term><term>Stroke</term><term>Stroke association</term><term>Stroke cases</term><term>Stroke risk</term><term>Stroke subtype</term><term>Stroke subtypes</term><term>Stroke subtyping</term><term>Study design</term><term>Study group</term><term>Study groups</term><term>Subgroup analysis</term><term>Subtypes</term><term>Subunit</term><term>Supplementary table</term><term>Systematic review</term><term>Telethon institute</term><term>Thromb</term><term>Thromb haemost</term><term>Trinity college dublin</term><term>Turbidimetric assay</term><term>Twin research</term><term>Twinsuk</term><term>Variant</term><term>Vascular health</term><term>Veterans affairs</term><term>Wellcome</term><term>Wellcome trust</term><term>Wellcome trust case control consortium</term><term>Wellcome trust centre</term><term>Wellcome trust genome campus</term><term>Wellcome trust sanger centre</term><term>Western australia</term><term>Willebrand factor</term><term>Wtccc2</term><term>Wtccc2 controls</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Finlande</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Maladie cardio-vasculaire</term><term>Consortium</term><term>épidémiologie</term><term>Génétique</term><term>Recherche médicale</term><term>Neurologie</term><term>Santé publique</term><term>Recherche scientifique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: End‐stage coagulation and the structure/function of fibrin are implicated in the pathogenesis of ischemic stroke. We explored whether genetic variants associated with end‐stage coagulation in healthy REFVIDunteers account for the genetic predisposition to ischemic stroke and examined their influence on stroke subtype.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Finlande</li><li>France</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Alsace (région administrative)</li><li>Angleterre</li><li>Bavière</li><li>District de Haute-Bavière</li><li>Floride</li><li>Grand Est</li><li>Grand Londres</li><li>Hauts-de-France</li><li>Hollande-Méridionale</li><li>Maryland</li><li>Massachusetts</li><li>Midi-Pyrénées</li><li>Nord-Pas-de-Calais</li><li>Occitanie (région administrative)</li><li>Oxfordshire</li><li>Texas</li><li>Uusimaa</li><li>Washington (État)</li><li>Yorkshire-et-Humber</li><li>Écosse</li><li>État du Mississippi</li></region><settlement><li>Helsinki</li><li>Leeds</li><li>Lille</li><li>Londres</li><li>Munich</li><li>Oxford</li><li>Rotterdam</li><li>Strasbourg</li><li>Toulouse</li><li>Édimbourg</li></settlement><orgName><li>Université d'Helsinki</li><li>Université d'Oxford</li><li>Université d'Édimbourg</li><li>Université de Leeds</li><li>Université de Londres</li></orgName></list><tree><noCountry><name sortKey="Evans, Alun" sort="Evans, Alun" uniqKey="Evans A" first="Alun" last="Evans">Alun Evans</name></noCountry><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name></region><name sortKey="Bevan, Steve" sort="Bevan, Steve" uniqKey="Bevan S" first="Steve" last="Bevan">Steve Bevan</name><name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name><name sortKey="Cheng, Yu Hing" sort="Cheng, Yu Hing" uniqKey="Cheng Y" first="Yu-Ching" last="Cheng">Yu-Ching Cheng</name><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name><name sortKey="Hodgkiss, Dylan" sort="Hodgkiss, Dylan" uniqKey="Hodgkiss D" first="Dylan" last="Hodgkiss">Dylan Hodgkiss</name><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G." last="Hysi">Pirro G. Hysi</name><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S." last="Markus">Hugh S. Markus</name><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name><name sortKey="Mosely, Thomas H" sort="Mosely, Thomas H" uniqKey="Mosely T" first="Thomas H." last="Mosely">Thomas H. Mosely</name><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><name sortKey="Rothwell, Peter M W" sort="Rothwell, Peter M W" uniqKey="Rothwell P" first="Peter M. W." last="Rothwell">Peter M. W. Rothwell</name><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D." last="Spector">Tim D. Spector</name><name sortKey="Sudlow, Cathie" sort="Sudlow, Cathie" uniqKey="Sudlow C" first="Cathie" last="Sudlow">Cathie Sudlow</name><name sortKey="Surdulescu, Gabriela" sort="Surdulescu, Gabriela" uniqKey="Surdulescu G" first="Gabriela" last="Surdulescu">Gabriela Surdulescu</name><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name></region><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name><name sortKey="Ferrario, Marco" sort="Ferrario, Marco" uniqKey="Ferrario M" first="Marco" last="Ferrario">Marco Ferrario</name><name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. 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Scott</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name></country><country name="Finlande"><noRegion><name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name></noRegion><name sortKey="Kaunisto, Mari" sort="Kaunisto, Mari" uniqKey="Kaunisto M" first="Mari" last="Kaunisto">Mari Kaunisto</name><name sortKey="Kuulasmaa, Kari" sort="Kuulasmaa, Kari" uniqKey="Kuulasmaa K" first="Kari" last="Kuulasmaa">Kari Kuulasmaa</name><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><name sortKey="Saarela, Olli" sort="Saarela, Olli" uniqKey="Saarela O" first="Olli" last="Saarela">Olli Saarela</name><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name><name sortKey="Silander, Kaisa" sort="Silander, Kaisa" uniqKey="Silander K" first="Kaisa" last="Silander">Kaisa Silander</name><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><name sortKey="Wagner, Peter" sort="Wagner, Peter" uniqKey="Wagner P" first="Peter" last="Wagner">Peter Wagner</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name></region><name sortKey="Gschwendtner, Andreas" sort="Gschwendtner, Andreas" uniqKey="Gschwendtner A" first="Andreas" last="Gschwendtner">Andreas Gschwendtner</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name></region><name sortKey="Arveiler, Dominique" sort="Arveiler, Dominique" uniqKey="Arveiler D" first="Dominique" last="Arveiler">Dominique Arveiler</name><name sortKey="Ferrieres, Jean" sort="Ferrieres, Jean" uniqKey="Ferrieres J" first="Jean" last="Ferrieres">Jean Ferrieres</name></country><country name="Suède"><noRegion><name sortKey="Wiklund, Per Unnar" sort="Wiklund, Per Unnar" uniqKey="Wiklund P" first="Per-Gunnar" last="Wiklund">Per-Gunnar Wiklund</name></noRegion></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Arfan Ikram, M" sort="Arfan Ikram, M" uniqKey="Arfan Ikram M" first="M." last="Arfan Ikram">M. Arfan Ikram</name></region><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name></country><country name="Italie"><noRegion><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B." last="Boncoraglio">Giorgio B. Boncoraglio</name></noRegion><name sortKey="Clarke, Robert" sort="Clarke, Robert" uniqKey="Clarke R" first="Robert" last="Clarke">Robert Clarke</name><name sortKey="Parati, Eugenio A" sort="Parati, Eugenio A" uniqKey="Parati E" first="Eugenio A." last="Parati">Eugenio A. Parati</name></country><country name="Islande"><noRegion><name sortKey="Helgadottir, Anna" sort="Helgadottir, Anna" uniqKey="Helgadottir A" first="Anna" last="Helgadottir">Anna Helgadottir</name></noRegion><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name></country><country name="Australie"><noRegion><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name></noRegion><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><name sortKey="Levi, Christopher" sort="Levi, Christopher" uniqKey="Levi C" first="Christopher" last="Levi">Christopher Levi</name><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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